To evaluate the antihyperglycemic activity of ethanolic extract of Butea monosperma leaf in alloxan induced diabetic rabbit. Healthy albino rabbits, from the Department of Animal house (V.S.S. Medical College, Burla, Orissa), weighing between 1.5 to 2 kg, aged between 6 months to 1 year were taken or this study. The animal under study were isolated and kept in a separate room. Alloxan induced (70 mg/kg i.v.) diabetic rabbit were given ethanolic leaf extract 100,200 and 400 mg/kg , P.O(PER ORAL),n=6} of Butea monosperma or vehicle(5%Tween80 2ml/kg,P.O.) or the standard drug Glyburide(0.5mg/kg.P.O.) for 6weeks. Fasting plasma glucose levels were determined after oral administration of normal and diabetic groups and Fasting plasma glucose, serum triglyceride and total serum cholesterol of diabetic rabbit were observed at 0,4,6 weeks, during highest dose of test drug (400mg).\r\n The ethanolic leaf extract of Butea monosperma leaf extract exerted significant hypoglycemic effect. . In diabetic rabbit reduced hyperglycemia significantly in acute study. In chronic study Butea monosperma leaf extract reduced Fasting plasma glucose significantly at 4 and 6 weeks interval and also lowered the serum triglyceride and total serum cholesterolafter4 to 6 weeks of treatment
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